SURFACE ENHANCED SPECTROSCOPY FOR NANOTECHNOLOGY, MEDCINE AND ART APPLICATION

Dovbeshko G., Gnatyuk O., Boyko V., Pidhirnyi D., Lebedieva T.
Institute of Physics of National Academy of Sciences of Ukraine, Kiev

SURFACE ENHANCED SPECTROSCOPY FOR NANOTECHNOLOGY, MEDCINE AND ART APPLICATION

During last decade we have been developing methods of surface enhanced spectroscopy (SES), namely, surface enhanced infrared spectroscopy (SEIRA), surface enhanced Raman scattering (SERS), surface enhanced luminescence (SEL) and their application. The phenomenon of SES is sensitive tool for probing the materials of small amount as well as for molecules with low luminescence yield.
Different substrates with special property should be applied for realization of the SES effect.  As usually we use gold rough substrates developed in the Institute of Physics of NAS Ukraine or metallic particles for absorption of the molecules under study. Due to excitation of plasmons in metallic substrate and increase of the dipole moment of absorbed molecules, a cross section of a process of IR and Raman intensity drastically increases, sometimes up to 105-107.
In the case of luminescence, the distance between molecule and substrate should be enough for realization of change transition between molecules and metal substrate.  
We got enhancement for nucleic acids in SEIRA and manifested a peculiarity of nucleic acids from tumour cells.
Other substrates that we developed are different carbon nanostructure (carbon nanotubes, graphene, etc.) as well different semiconductor in the visible and IR region with negative real part of dielectric permeability.
Here we discuss possible mechanism, as well as advantages and disadvantages of SES for identifications and analysis of biomolecules and their conformations, nanoparticles, stains and its origin.
We thank to Faemcar Project FP7-PEOPLE-2012-IRSES and Poland-Ukrainian Project 2015-2017 for financial support